◆ SpookStack

Approved For Release 2003NQ9/AQS [EI-RDP96-00788R001300020001-6 ST-CS-01-169-72 July 1972 2. Amine synthesis inhibitors a. Inhibitors of catecholamine synthesis: e.g. alpha-nmethy1-p-tyrosine b. Inhibitors of serotonin synthesis: e.g. p- chlorophenylalanine B. _Drugs which enhance amine Synaptic activity 1. Psychic energizers a. Inhibitors of monoamine oxidase: hydrazines and monoamine analogs--e.g. iproniazide, tranylcypromine, amphetamine b. Inhibitors of amine uptake: dibenzazepines and miscellaneous derivatives--e.g. imipra-~ mine, amitriptyline, cocaine, amphetamine c. Amine releasers: amine analogs—e.g. amphe- tamine, tyramine 2. Amine synthesis stimulators a. For dopamine and noradrenaline: L-dopa b. For noradrenaline: L-dihydroxyphenylserine c. For serotonin: L~5~hydroxyt ryptophan PART B - Other Areas of Soviet Research in Psychopharmacology 1. (U) Barkov and Gurovich (212) reported on the effects of tripthazine (stelazine) and aminazine (thorazine) on emotional behavior. The compounds were found to inhibit aggression but prolong the fear reaction in rats, 2. (U) The Soviets have conducted experiments which use an automatic, multichannel register of motor activity. The instrument independently records all the movements of the animals located in a special chamber and transmits the signal to 40 counters. Kruglov is using a modern radio-electronic device which can record the signals, of milli-second duration, by which neurons transmit information to each other. Kruglov and his colleagues have established that morphine, aminazine, and similar substances inhibit the signaling rhythm of nerve cells. These experiments yielded many new tran- quilizers and stimulants. None of these "new" substances were described. The Soviets claim that neurotropic drugs are now making it possible to intervene in the most important processes taking place in the organism. No description of what important processes taking place is mentioned (213). 74 UNCLASSIFIED