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- ; ‘'V Investigation of the seed of Rlvea Corymbosa (ololuqul) , > . ‘ Summary of work, November 1, 1955 - September 25, 1956s 1 Physical examination of the seed used in this work .reveals that two w types” have been under investigation, : Taxonomloally all the seed have been called Hive a Corymbose . although one variety (the seed are the larger of *the two varieties) originated in Mexico and one Variety originated in Cuba. The literature on the subject of ololiuqui, as 7777 far as I can ascertain indicates: that its use as a psychic:: drug has been restricted to Mexico* This data ©lone would indicate the probability that the Cuban variety lacks some physiologically active compon ent: which the Mexican variety contains, ExperimentaliWoi’k in t this laboratory has been largely restricted to the Cuban variety (snail seed since only a very small amount of the Mexican variety has been avail'iibleV"'"":i3Ke^heinIcal v/ork, although not designed to compare the composition of the two varieties, has indicated some difference in the two, i: Also physiological - tests on humans arerlndlcative of a difference in the two varieties, ihis work is: much too inconclusive to be much more than speculation at thisr timer7 In addition to the isolation of glucose and hydro- quinone as constituents of ololiuqui as reported in the last progress report, two crystalline fractions have been isolated which seem neither to be alkaloid- or glycoside, , ;7 Due to the small quantity of seed available the amount ’ ' of these crystalling fractions 7 is extremely small and ' r ; little more than* qualitativ e tests have been made on them, . . ? Experimental techniques , es pec ial ly in ex fraction and , • .7~ separation have been perfected which will be used to . : v isolate pure components of the drug which, just today, | has become available Insufficient quantity to make the investigation profitable. - Plans for future investigation: Now that 50 pounds of the Cuban variety and 10 pounds of the Mexican variety are available, the following lines of investigation will be: actively pursued, 1, Determine conclusively rlf there is a chemical ' difference in the two varieties of seed, 2, Obtain as many ! *pure” components from each variety, ' using previously perfected techniques, as Is possible* —-:r- - t--:-:- - 3. Submit for physiological testing each "pure” component, 4, Subject each ’’pure” component to chemical examination to determine the type of compound, whether it is a Imown compound and its chemical composition if it is a new compound, WARNING NOTICE SENSITIVE INTELLIGENCE SOURCES AND METHODS INVOLVED