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T # ward determining the ways in which the resultant psychophysiological alterations can be quantified, and the ways in which these altered states. can be utilized in the production of increased influence- ability in normal subjects. III. NEW STUDIES OF PSYCHOPHYSIOLOGICAL RELATIONSHIPS AND REACTIONS TO ' STRESS, EMPLOYING HYPNOTIC TECHNIQUES A. Current experiments have definitely established a number of ways in which hypnotic suggestions can bring about states of marked psychological stress in suitable subjects, with resultant changes in neurophysiological and neuro-endoerinological function. It has also been shown in preliminary studies that hypnotic methods can successfully be employed to protect individuals from the psycho- physiological reactions to noxious stimulation. These observations constitute an indication that more control can be exerted over the autonomic nervous system than has been previously supposed. Coupled with the recent development of autonomic drugs of highly specific activity it is now possible to isolate more precisely than ever be- fore the exact means by which and the precise degree to which psycho- physiological reactions occur to specific types of stress. B. It is proposed that the combined use of hypnotic techniques and auto- nomic drugs be exercised in initiating some original studies on the nature of psychophysiological reactions to stress, IV. TECHNICAL CONSIDERATIONS All of the above-recommended experimental procedures will require special equipment, special methodologies, and special skills. In order to make possible a continuing research program in this area, a psycho-