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;*4 * .) i on \ rn *yj SIlliiE > jo220 . 52 6 rn 2fte research to be undertaken during the twelve month period for which financial support is requested will “be devoted to the continued analysis of the neural and endocrine mechanism of stress and the chemical agents that influence It, The screening procedures are based largely upon a further analysts of phases of stress and the influences of this physiologic behavior complex upon both body and skin temperatures as detailed in the accompany- : ing report . The chemical synthesis of new compounds will be continued & at the ^j^^^^KKKtKKtjK^^underthe supervision and und<er the supervision & C. These chemical agents will be screened for their capacity to provoke stress or tp suppress the stress reaction in it3 acute or chronic phases . Animal testing will include pharma- cologic screening and proper toxicity studies, of these compounds as , 4 " « heretofore . — ^ — V Chemical agents that have been found active and "within a suitable toxicity range will be subjected to oltnical screening on appropriate patients, the initial screening being carried out on advanced cancer patients* The amount of money devoted to chemical synthesis, however, has bean further reduced, Chemical compounds - available from biologic sources as well as those synthesised in the project will be screened, particularly those that are active in either raising or lowering body temperature. heretofore any agents whioh prove to be of interest in cazLaar-jaL.il be subjected to further evaluation both on transplanted