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r ^ - ’s i»'-' .- ’ ;;•**.* i t "i t RESEARCH PROPOSAL 1958 - 1959 - The research to be Undertaken durimg the 12 months ^ . , — " jm period for which financial. support is requested will be deroted to=r~ an analysis of the neural and endocrine mechanism of stress^ and * • • . the chemical 'agents that influence it. The screening procedures ^ ‘si are based largely upon the analysis of the General Adaptation Syndrome that has been worked out in rats during the past year, an outline of which is appended. ' "5 The chemical synthesis of possibly active compounds will y be continued at the and the and these chemical agents will be screened for their capacity to provoke stress or to suppress the stress reaction in * . its acute or chronic phases. The tests employed on animals will ~~v be used for screening and proper toxicity studies of the compounds will be carried out as heretofore. * < Chemical agents that have been, found active and within a suitable toxicity range will bre subjected to clinical screening on appropriate patients, the initial screening being carried out as heretofore on advanced cancer patients. The amount of money devoted to chemical synthesis will be much reduced and chemical compounds available from "various sources as well as those synthesized in the project will be screened. 'As heretofore any agents which prove of interest in cancer will be subjected to further evaluation both on transplanted animal ^ ® ’ -s - tumors and on cancer patients. This aancer phase of the project- !