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-T K : . fr-/n wHM^ * 1? Janiary 1957 } MEMORANDUM FOR: THE RECORD SUBJECT: Project MKULTRA, Subproject 45 V^VJ H v i* /i U The scope of this subproject includes' all those activities now engaged in by the under the direction of TSS/CD with the exception of those cutout functions specifically mentioned in connection with other MKULTRA subprojects. In general, the research effort under this subproject will continue along the lines laid down in previous years.' These involve the synthesis and pharmacological and clinical evaluation of compounds of those chemical families known to have application in the psychochemical and "K” fields// Also, last year, research in the field of so-called ’’natural toxic psychoses” was undertaken and will be continued during the coining year. 2. , The attached proposal from^MMHHHIHNljB' because of its unclassified status, is couched in therapeutic terms; therefore, a certain amount of translation of its substance is warranted, Yery briefly, the study on "toxic psychoses" has permitted the possible sources of reversible psychotic and/or comatose conditions to be narrowed down to a workable maximum number about which critical experiments can be designed to test various hypothetical chemical mediators. The chemical synthetic and screening program (some 100 new compounds during the year) has turned up three compounds of different families which are of- fundamental importance with rela- tion to the goals of this project. These three compounds include an orally active material which reduces blood glucose; another which acts by all routes, including percutaneous, and which appears to be the chemical mediator of "stress", and finally, a compound which is also orally active and v&ich is a very potent new type of barbitur- ate and possibly alcohol antidote. It is now proposed to reduce the volume of the synthetic chemical effort_in order to work out the ‘ j pharmacological and clinical aspects of these and closely related substances. 3. serves as a general consultant to the Agency, provides services of a sensitive nature on an ad hoc basis, and serves as a cut-out in procurement problems. 4. The total cost of this project for a period 'of one year will not' exceed $100, 000. 00. Charges should be made against Allotment 7-2502 -10-00l/f, L; .’LSI