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MEMORANDUM FOR: | THE RECORD SUBJECT: Project-MKULIRA, Subproject 45 1, |The scope of this project is intended to enc activities now engaged in by the under the direction of TSS/ These activities take the form of three lines of biochemical investigation, namely, the Curare-like effect of certain thiols, the preparation of hydrogenated quinolines and indole alkaloids and a program of investigation of toxic cerebral states. This last investigation will include bio-assay and chemical- 7 analysis of various body fluids of animals in which cerebral toxemias have \been produced, It is the aim of this program to endeavor to understand the mechanism of such states as toxic delirium, tremic coma, and cerebral toxicity from poifsonitg. In order to continue the G) -established "cover" activities of end to make available a ) pool of subjects for testing purposes, effects of compounds resulting fromthe above program will 4% evaluated. nee ie : 2, The attached proposal from SRM indicates the extent of the investigations that his facilities will allow him to ‘carry out on the materials developed in the three lines of research © referred to in paragraph one; 4: as certain other materials of interest to TSS/CD, So serves as a general consultant to this Division and provides cover arid cut-out facilities to the ” Agency. 3. The total cost of this project for a period of one year will not exceed $100,000, Charges should be made against Allotment 6-2502-10-001, : 7 be has been requested to submit a summary account- ing or a copy of thi fannual audit. report be made available for the sponsor's inspection, Also, it has been requested that any unex- pended funds shall be returned to the Agency. Title to any permanent equipment chased by funds granted hall be retained by’ the SA lieu of higher overhead rates,’ * other than its activities as a cut-out o: DOSY enority of 75 te: June E2 IgggeT: ch BY 1987475 _~