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proposal simiFCT' The Testing In Animals and Human Volunteers of Chemicals and Biochemical* Which Alter Behavior. PLACE: The New Jersey Neuro-Psychiatric Institute ' The Bureau, of Research In Neurology and Psychiatry Princeton, New Jersey (P.O. Box 1, 000) PRINCI PA L INVESTIGATOR: Carl C . Pfeiffe r , Ph. D. , M . D. GRANT ADMINISTRATORS^ NewMersey Mental Health Research and ~~ ' Development Fund, Inc. I Jill Lane, Trenton 8, New Jersey Henry P. David. Ph.D., Secretary-Treasurer It Is proposed to conduct screening and range finding tests on volunteers with chemical compounds of known behavioral activity.: Studies will be conducted on derivatives of selected biologically active compounds to deter- mine their action on the central nervous system of man. In addition to these Investigations, the following work will be undertaken: 1. Pharmacological testing will be conducted on animals utilizing candidate hallucinogenic chemicals, 2. Studies will be conducted on compounds of relallvly simple configuration to assess their ability to tnhlbit trained behavior In animals utilizing the condition avoidance responses. 3. Studies will be conducted of compounds In normal human volunteers for possible behavioral changes utilizing compounds provided by the sponsor. 4. Quantitative studies of the EEG in animals and man to determine stimulant or depressant effects of candidate mater- ials.