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Note: 10/15/1999 Note: Protocol B00-03 rabbits. eriment #1: To: Washington ou ® From: Washington Field Re: 279A-WF-222936-USAMRIID, 1/11/2006 This is an aerosol challenge utilizing the "Dugway Material" according oy There is no entry in the RMR Record for 1029 to indicate that[____] was given a sample of RMR 1029 or that a sample was given out to anyone in this time period. In an entry into one of Ivins' notebooks on 9/17/1998, he indicates that he provided GLP Ames spores for the aerosolization of monkeys. "GLP Ames" is another term used to reference RMR 1029. Expo; 0-0002, Protocol _D99-02 PI: Tech: Ba A ock Room Hood 1, 3 NHPs exposed There_i 1o entry in Ivins' logs to indicate that [| was given a sample of RMR 1029 or that a sample was given out to anyone in this time period. There is no documentation to veify that this challenge utilized material derived from RMR 1029 or in any way linked to Dugway. Title: Selection between two recombinant PA preparations for development of a potency assay and a correlate of immunity in Objective: The first objective of this research is to determine in the rabbit aerosol challenge model the potency of two recombinant PA proteins when combined with Rehydragel adjuvant. The hypothesis is that there will be no difference in the potency of the two recombinant PA proteins. A second objective of the research is to determine the efficacy of the rPA vaccine and to evaluate the serological response to immunization by ELISA and toxin neutralization assay (TNA) to confirm the correlate of immunity in the rabbit. bE bIC