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Approved For Release 2008/0040 : CIA-RDP96-00788R001300020001-6 ST-CS-01-169-72 July 1972 of LSD on Soviet troops. There is a group at the Institute of Physiology in Novosibirsk. No details on their work is available. The relationship between LSD, serotonin, and motor components of behavior reactions is being studied at the Donetsk Medical Institute (201). The Soviet research in the area concerned with the action of bioamines, e.g., adrenaline, serotonin, and nor~ adrenaline, which the Donetsk group is studying, will be discussed later in this report. Studies concerned with the reversibility of pathomorphological changes in the brain of rats after chronic administration of LSD were going on in 1971 at the Moscow Medical Stomatological Institute (202). The First Medical Institute imeni I.M. Sechenov has reported their work on the search for antagonists for hashish and LSD (203). Kudrin reported that Haloperidol (a butyrophenone tranquilizer) injection in combina- tion with Phenitron (a propiophenone adrenolytic) prevents cats from the development of LSD-induced psychosis and catatonia. This is an important aspect of Soviet LSD research as it indicates their possible interest in military medical defense against psycho- warfare agents. Popova has reported on the effect of LSD on the structure of neurons and interneuronal connections. The author states that her observations suggest that the central effects of LSD may be related to changes both in synapses and in the cell body (204). 4, (C/NFD) This study has attempted to establish the possibility that the Serbsky Institute of Forensic Psychiatry in Moscow may be one of the main Soviet facilities for studying controlled offensive behavior (see PART I). I.P. Anokhina of the Serbsky Institute reported in 1970 on the effect of LSD on the neuro transmitter systems of the brain. The experiments brought evidence that the site of action of LSD is in the midbrain reticular formation and in the limbic system. Anokhina also believes that LSD inhibits monoamineoxidase (MAO) activity (205). The experi- ment reported in the open literature is scientifically genuine, of course, but the important fact is that the Institute is studying LSD and other psychotropic agents. Since most of the Soviet LSD literature is from institutes in Moscow, it might be conjec~ tured that there is a concentrated effort in the USSR to determine the basis of action and uses for LSD and other possible psycho- warfare agents. 5. (S/NFD) Until March of 1968, there were three chemical plants located in Czechoslovakia conducting independent research on CW compounds. As late as March 1968, they were working on super-active compounds based on materials such as LSD and mescaline. ' 68 NO FOREIGN DISSEMINATION