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v E2 IMPOST ; CL BY 187475 MEMORANDUM FOR: THE RECORD SUBJECT : Continuation of MKDLTRA, Subproject No. ^5 1. The scope of this subproject Includes all those activities ncw^ngaged in by under the direction of TSD/HB with the exception of those cutout functions specifically mentioned in connection with other MKDKERA subprojects. In general, the research effort under this subproject will continue along the lines laid down in previous years. These involve the synthesis and pharmacological and clinical evaluation Of compounds of those l *»« imoim to have application in the psychochemical and ”K” fields* During the coming year it is planned to concentrate more directly on the more practical aspects of the "knockout" problem. Enough new potent substances have become available lately to make such a change in emphasis worthwhile* In connection with this change it should be noted that certain findings made in a <2 MHHMRI project at which cannot Jbe further exploited at 1? that facility will be pursued at MHBMHfc the future* For this reason it may be necessary to supplement the findings of this subproject from time to time during the year due to increases of scope. ^ 2. also serves as a 'general consultant to the Agency, provides services of a sensitive nature on an ed hoc basis, and serves as a cutout in procurement problems.