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produced glycosuria, which disappeared in 48 hoars. The blood sugar of the . . • -• animals is lowered; no acetone bodies agqpear in the urine. -In the next experiment the compounds were administered oraUy, intra- muscularly or intravenously toeeaeer patientsjmd werefoundeffective in controlling * for a period of 3 months (to-date) diseasesin the lymphoma and leukemic clans'. These patienta have been able to tolerate the compound, and although it initially produced lowering of the blood sugar, if the dose is not increased, there is acquired tolerance to • • V - * - the hypoglycemic effect of the drug. In the next experiment, the drug was administered to four diabetic The blood sugar can be reduced in fresh diabetics-notpreviously subjected to from a level of 350 mg%to 250 mg^by the administration of 250 mg. of the Diethyl is more potent than dimethyl derivatives, hi other diabetics the blood sugar levels can be satisfactorily controlled for a period of 3 to 4 weeks on dogoo but after that time tolerance develops, and the dosage must be raised. The compound lowers blood sugar by glycogen storage, but does not increase the capacity to burn sugar. Insulin must therefore be added. ' In another groiq> of experiments about to be undertaken, it is to administer these drugs to hospitalized diabetics and study the effect on function" of large doses of th<* compound. Several of the cancer patients on the compound have complained of fogging, which is accompanied by complete relief from pain on high dosage. This ™«rt» l fogging, of course, is not experienced by diabetics and must be a function of the glucose level in the brain. It is planned to synethsize a group of allied compounds and to broaden this line of investigation. It is also planned to utilize a Warburg apparatus and electrophoresis t in order to elucidate the exact phase of glucose metabolism that is by these