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SKI - - -5^* : -<.- ~ P '<:-'* VF -\^~' -.:’• '.a ‘T^~- - o'SHp.’v5 *.. r -, * -*?>* a. -> .-. 4" ?;v c >' -W ::. f-z :>';V :: /.**.- ; -V- Xereovsr* the modern tendency to class the diffuse collagen diseases* neb as acute rheumatic fever, rheumatoid arthritis* dlsseminatedlxipos aryth—utosaa. polyarteritis* capillary platelet thrombosis, and sclsroderoa* aa modlfisd forma of Artlma 1 * phenomenon indicates that there are additional charactarlstlca a. or foaetiona of the nntigan-enfibody "reaction that have set yet been elucidated. for a number of years the author has been convinced that one of the functions of the antigen-antibody reaction la to prolong the iaflassantory process by liberating irritating amines, which for vent of a better tern hare been described in the literature as "salon bodies** It appears that Haturs'e oldest oad nest reliable naans to conhat injury and Infection is the inflemmatoxy process-, and although the Issnme process is Bora nodarn and efficient, It nonetheless is still mistrusted and provision ia nods for antigen-antibody onion to prolong inflamnatlon under special elrcniBstances. She foot that the flonbinatlon of antigen and antibody union can itself initiate an lnflamatory response ia only too well denonstrated in oases of sesame* nrtiearla end bay fever-. It is only with the greatest attention to details that an Incipi- ent ease of hey toror can be differentiated from a common cold* Bxparl wtatlon %rlth several irritating mines has finally permitted the characterisation of a substance* which we have tensed "alarmine,* which ve believe is an essential part of antigen-antibody reactions* She liberation of soda aa amine. substance daring the antigen-antibody reaction has throe separata functions* 1. She irritant amine or alarmine prolongs the local lsflammatoxy reaction* Shis it does by alteration of the capillary wall of the affected locality ia a more narked fashion than histamine or *H* substance. 2. It triggers the general adaptation ayndrosaa In the adrenals, releasing cortisone, which increases the amount of l^wniae globulin liberated through the b-aaJe-tqp of lymphoid tissue* If repetitive injury does not occur* the /\V z'"