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from the knowledge of the formula Hid tbs effects on tta• akin aad adrenal, it was assumed that ona of too things might explain the resalts* She toxicity ot tbs compound,jnight lava destroyed tissues sad In this «v caused adrenal hyperfunction through aa alam reactions crthn'compdttnd could be Skin to • 1 : V ' . _ ... that studied by Landsteiner* in which phanylaatnae acting as haptenas combined tdd proteins to produce antibody naetieuf tint prodaeiag an alarm reaction vith first hypertrophy and then exhaustion of the adrenals through an allergic response* the results vehe puszling, hat interesting. rata were painted daily on the surface of the shared skin of the thigh over an area of epproxinetely 2 x Z em* These vere Wiisbar rats weighing 120 On* droop 1« consisting of eight, ratty vaa painted with a 3 per ceat solution in aesaae oil daily except Sunday* Four untreated rats served as controls. drag II* consisting of eight rate* vaa painted vith a 1 per cent solution g; in sesame ©n daily except Sunday* Four untreated rats served as controls* droop 111* consisting, of eight rats, vas painted vith a 0*5 per cent _ •i,- solution in sesane oil daily except Sunday* Pour untreated rats served as controls* gro-trp r> loeawee* She rate died between 10 and 15 days, on the average of 12 days* They shoved stationary weight* The skin shoved some _ ulceration and veslclesy hut not as severe as vith the 5 per cent solution* Grossly, the adrenals did not appear to he narkedly enlarged* The spleen and - lymphoid tissues shoved slight atrophy* The lungs shoved increased secretion in the bronchi* and these rats ssened to die of pulnonary sdeaa and congestion* The heart vas dilated. Microscopically, the pulnonary edsna vas due to exudation of plasma (so-called lysphorrhagie ) about the snaller blood vessels in the lung* The basement membrane of theee smaller vessels shoved smudging and dissolution . and the endothelial lining cells projected into the lumen and sons vers ”f ‘ detached* In the heart there was an accumulation of spindle cells c^wss (endothel- — ial cell9 liberated by dissolution of adjacent capillaries) lying between