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the myocardial fibers, share. they bed bees separated by edsaa fluid from leaking vessels similar to these found la the lungs. Soma of the sections shoved typical Asohoff bodies (ytgs.2 and 3)* Chore -were numerous dilated vascular 1 space* lined by a single layer of cede thelites and easy extrsvasated erythro- cytes. In the synovial membranes of the knee Joint the capillaries were dilated and filled with red cells, boss of which vers tindergoing lysis, Oxers was smudging of the ground substance immediately beneath the nedothellal lining layer* In the bone sorrow the capillaries sere slnilarly dilated end there sere areas of coagulated artravasated fluid* Che bone marrow elements were . Intact* Che 9lean shoved almost canplete disappearance of lysphoid pulp* Che surviving gerninal centers shoved evidence of necrosis. Other organs were negative* Grotto II* Kiddle Cosago.. fhese rate lived a maximum period of 9 months, and they died between the 30th end 60th day. Chey shoved failure to gain weight, At autopsy* grossly* the lunge were ooageeted and shoved pulmonary edema and. increased secretion in the bronchi. There was some thickening of ties arteries in the lungs* but not the veins. Bisto logically* thsre was som *onion peeling" of snail arteries and arterlolas* but eons of the controls shoved similar changes* The heart was dilated and the adrenals were enlarged. Microscopically* the adrenals shoved hypertrophy and hyperplasia confined to the cortex. Che spleen and lymphoid tissues were similar to Group I* Microscopically, the spleen ehoved reduction of lymphoid tissue and necrosis of the germinal centers. Chsro was increased number of macrophages in the pulp with nux&roua binuclaated forms. (yigture-U)^:!. • Che heart showed focal fibrosis with Anitschkow's cells and some Aschoff bodies* and about this there were areas of fibrinoid degeneration* Che Joint Changea in animals that died early were aiallar to Group I* Other organs were negative. Group III . Low Dosage. Some of the rats in this group died 6 weeks after the beginning of the experiments, but some were still living 3 months