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; i l <1 .. yjyijjpi Istsr* jit satopsy, the outstanding finding wee endothelial proliferwtiin c* the lining of nail polaonaxy wowla* so that their liman wee practically occluded* . Sene of the- weasels looked like they were being recanallsed and seme looked almost like golaeruli. The endothelial proliferation in places extended out into the _-J adjacent septa of the lung* This was found In only ten sets* who apparently inhaled the alarmine while licking their wounds* (fig* $). The spleen me practically devoid of lyepboid tisane aid nearly doable in else* The pulp contained may macrophages with numerous foaa cell types and these were sons granulocytes hot practically no lynphocytca* A fan germinal centers wars Intact* The heart showed areas of fibrinoid degeneration and typical Aschoff bodies with Anitschkow*s cellar In other sesdels* the walla of the capillaries were disintegrating* and the liber* ated endothelial cells accumulated about arterioles to fom typical Aschoff bodies* The adjacent sycfibrils were nefcrotic and hyalinlzcd* These changes net as widespread as in the rats on higher dosage* The knee joints on microscopic examination showed rheumatoid arthritis with the formation of rheumatoid noddies in the synovial membrane* (Fig* 6)* The bone sorrow was not remarkable* The brains and kidneys wars normal in appear-* once* In the region of the kidneys end pancreas saall to aediua-eised 'vessels showed thrccbcnecrosis or narked endothelial proliferation similar to that found in the lungs* (Fig* 7)* ~ ~ The skin shewed epddeiaal hyperplasia in the painted area* In the sub- cutaneous tissue of thf Se rats there was marked edema simulating a stage in scleroderma, except that the location was net in the derma and was unaccompanied by atrophy of the heir follicles* In the voluntary muscles beneath the painted areas there were also collections of plasma cells and lymphocytes and to blood vessels simulating the lesions of denaatcoycaltis* (Fig* ?)* In the liver there were increased numbers of cells with acidophilic •I* 1 .