◆ SpookStack

„ .’f i,.*- If-- - , & . cytoplasm and blnucleated forms, Sons of the Teasels showed endothelial proliferation as ia the longs* there seeaed to he acidophilic resembling Cotmcilman's bodies* - Scea af the liver'cells sore vacuolated; others showed hyalin droplet deganer&tion, and the nuclei were of varying siss and density, (fig. ID), the control rata showed no significant changes, Effect of Alarming on the Cement and Ground Substances, The primary effect of alanaina is to produce hydration of the mucopolysaccharide structure of basement membranes and ground substance in mesenchynal tissues. The most sensitive tissue component is the cement substance in tim endothelial well of capillariesj perhaps because this is the site of the <w4*.4ai contact in the tissue. The earliest change la softening which allows the capillary well to stretch asd form aneurysmal dilatations, (Fig. IX) , In ths basement membrane behind the endothelium In pxecapiUary arteries and in arterioles, this hydration can be seen histologically as a chain of snail bubbles* which m ban* termed beading, (fig. 12). In the next stags the capillary mil disintegrates and the Tiabls endothelial calls and intact erythrocytes spill into the tissue spaces, (Fig. 13), In the heart the liberated endothelial cells from th<* coronary capillaries migrate toward damaged arterioles and" ~ tons, psrdvascular Aschoff bodies , _ In subsequent stages there is sore vide* spread damage to the connective tissue components. This results in fusion cf erythrocytes, condensation of ground substance to form f ibrinoid degen- eration and liquefaction cf other portions of the ground substance probably due to its infiltration by plasma leaking froa the ruptured capillaries, and shredding of the collagen fibers with subsequent necrosis of these structures and adjacent muscle cells, Depolyserization and hydrolysis affects the nonviable cement and at.V I i Vii (till