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ground mbituei and filters of vessels and connective tiim*, dacongwses these nonviable eoqnantt of stromal tlimw, Aieh are technically ' T ’ 1 i 4 kaeta so mucopolysaccharides sad sclcroproteias* this target tiaras la the identical *tractors daangod by ^ritaain 0 dafldanoy sad by fcyaluronidaM, sad ' it la tha mm structure idildh la strsngthsnsd and readers! mors resistant to this offset by cortisone* diamine is, therefore, aa antagonist of vitaaia C and cortisone and tha artificial tanning substances, such as tha quinolines*. If M analyte thia pathologio saris s of responses into its major eempon- •ats, vs find that intense injury by alarmlne la an exaggeration of the patho— logia process found in th# simple fcealliqt of wounds^ sfeiefc has boon torsod organisation* Here the injured tissue releases minimal amounts of alaratins adach produces matrix hydrolysis and capillary aaeuxysaal dilatation of tha capillaries duo to the flaccid state of their tails* Because of the p.hemn+.ar-K of the capillary endothelium for tha hydrated matrix in the injured area, i capillary sprouts are dragged into the sound* The histologic pic tore that rasslta is known aa granulation tissue* Tha ptiaary effect of alarm!ne in producing the changes of rheumatoid carditis, rheumatoid arthritis and polyarteritis is on the basement membrane of blood -vessels and not primarily on tha collages fibers of eoaaeatiTo tissue* According to the. latest chemical. studies of_collagen, the fibrinoid degeaerai- tion where it occurs in connective tissue does not involve the collagen bundles of well-formed connective tissue fibers* In order to emphasize tha exact sequence of events it la important to review tha histological and bloehealcal composition of connective tissue* Sobb-Smith? has defined connective tissue aa a continuous matrix varying in consistency from the lispidness of bhartoa’s Jelly of the umbilical cord to tha hardness of bone in which lies an interlacing fabric of fibers of different and is bathing isolated or closely set cells* sorts/ This continuous matrix pervades the spaces between organs and major