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+ t. *lea. ?» »' i&f tendency for alanrtaa to farther prolong ths Inflasnstory reaction 1* ia- iiWWLly aAnml evrtleal honeu» riklA nadoi ths inflamed tissues via tbe circulation. thl* cortisone neutralises the local alaratne offMi sad further lirflanutMy response U not provoked. 3* If the imbbI of tfUfit 1* Unasually greet er if repeated to th« utigsa alarmina 1» sot neutralised hut prolongs the graaral adaptation syndrome and at tha mu tlua provoke* an «m nr* marked vascular change, which ha* been grrononljr termed collagenous aecrosla, but is instead a aisgalded form of incipient fibrous repair* It is tbs purpose of theprssent communication to describe the motions of sniss irritants of ths mlamlaa class, and to show their rola in triggsiw ing tha alarm reaction in tha adrenal and also their role la the production of so-called diffuse collagen disease, tfe have bean able to produce for the first tine experimentally rheunatie ayoearditls vith Aschoff bodies, rheuma- teid arthritis with rheumatoid nodules, and a variety of vascular lesions known as diffuse collagen disease, by irritant amines of relative siaple chemical structure, (fig. 1) la the original expertneat 24 rats were painted trie* dally vith a 5 per cent solution of dinethy1 disnallne. She solution in ssssne oil was sppllad to a shaved aria of shin on ths thigh epproxlaetely 2x3 cm. in else, fhs rodents died within 36 to 72 hours. Yesieles or ulearatlons of tha skin appeared in all rats living sore than 49 hours. She offset on the epl&erals was siallar to that of nitrogea-siustard, vith destruction of the basal cells of the epidermis and veaiculation of nuclei. 2n some of these rats at autopsy the adrenals were slightly enlarged and hemorrhagic. It was. therefore, decided to under- take chronic tonicity studies and to study in detail ths effect of the com- pound on the systemic organs. Instead of restricting the study to ths Skin. •