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If the parted of itnu is prolonged or eontlnasd* stisolution produces cortical hyperplasia and eolargsaent of the adrenals* fhiscortical hyper* taxation remit* in alteration of carbohydrate^, protola and fat netaboliaa. fhere is also «s elevation of sodiai electrolyte* la the sera* Altfe laoroosos the resistance of the will by expanding **» nstabohic pool and the eoltaoe of tissue fluids* .At the sene tins, there is increased excretion of such products os potassiun, histsainss and urio sold*. Simultaneously, the inouaa nechanisna are reinforced tor destruction of lyapbocyte* reselling la lynphoeytopenla, eosinopenlo. aad laucocytoais. Since lyapbocyte* stors <««* globulins* thsir disintegration leads to a rapid rise in antibody titer. If exposure to stress continues, the adaptation syndroas fails aad la followed "by exhaustion*. Selys believed that the excessive drain on the anterior pituitary end adrenal cortical horaoaes incident to protracted or repeated trauaa say result in cardiovascular renal aad joint disease* end he lists such entities as aspbrosclero# is* polyarteritis* carditis and arthritis an adaptation diseases* However, tbs consensus of present day opinion holds that thaae are foras of diffuse collagen disease resulting fron hyperinsnaity* Talbott and Jorxnndis^ believe that tbs etiology of these conditions is still unknown end that -no investigation has successfully reproduced then in aaisala except for polyarteritis in rabbits aad the occurrence of diseeninated lupus erythematosus in hunans following the administration of the aatihypertensive dreg, hydralaxlne (Aprssaline). In the authors 1 opinion, it is ndf possible to denonstrate that Siailsr Irritating amines are released in tissue daaagefv*here they have been customarily referred to as *H* sub stances, aad In the union of antigen mad antibody, where they have been tensed “union substances. - These irritating