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4/7/2000 4/10/2000 7/7/2000 Note: 7/17/2000 Note: 7/18/2000 Aerosol logs Protocol FO0-11 Objectives: rabbit model. To: Washington i @ From: Washington Field Re: 279A-WF-222936-USAMRIID, 1/11/2006 show that a total of 56 animals were exposed during this part of study BO0-03. bé Room[__| Hood 1 & 2, 40 Rabbits exposed b7c b2 Exposure 00-023, - b7F pr: L____]_ Tech: Ba tock RMR 1029 Room| Hood 1 & 2, 36 Rabbits exposed Exposure 00-024, Protocol BO0-03 PI: Tech: Ba A ock RMR 10 Room Hood 1 & 2, 34 Rabbits exposed Rerosol logs show that a total of 110 animals were exposed during this part of study BO0-03. Part 2 of multi-part aerosol study (B00-03) 40 ml used It is assumed that this 40 ml was used for the 7/17/2000 and 7/18/2000 aerosol challenges. Expo; -039, = PI: Tech: Ba Ames Stock RMR 1 Room Hood 1 & 2, 28 Rabbits exposed 3 x 10? cfu/ml This was the first aerosol challenge using the new collison nebulizers. Protocol B00-03 , 28 Rabbits exposed 3 x 10° cfu/ml Title: Efficacy and immune response of two lots of AVA in the rabbit model of inhalational anthrax. 1. To determine if 2 lots of AVA (FAV 009 and FAV 032) made several years ago, are still efficacious in the rabbit model of inhalational anthrax. 2. To compare the immunogenicity of the 2 lots of AVA in the