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.>. v^;-' : -v-i;V^i/:>r}: -v - ' :?. >;' • :"'** 'Xr »*• - '*'- -—'** '/^ . S ,V>r * ’“. . ’ '* .. ' J *- ». ' f?*: ' ••'•Vii •*.:«€s*^.'-v<. V. . £>*’- "' !? -' V-i"-.;-' •'•«•?' •^•‘- - V“ -?- . .V^V *.• >VS •2?'..'' £,- -’... '••' . . ;. A.T-J . ’..-.f— i- — .1- UA . J..AA . _ 1 ^?t^At.;thia 'point - work, was-': suspended due to my change of ^•poi^tiona, ^ ' •' : . I ; ' f '.y ;V Proposal '• Future plans call for the following. . v 1.^ The use of larger quantities of the seed. . (Originally only a small quantity was available, now there is a large quantity available.) 2. ' Considerable work on the use of ion exchange resins in order that this technique: can be used on aqueous / • . extracts of plule withbutr the possibility of • - losing some of the active principles. . 3. Work to be continued on the isolation of glyco- alkaloid(s). There Is some Indication in this -:V - ;/ investigation : that in addition to one or more ... . 1 glycoalkaloids thefe: is also uncombined: alkaloid. . ' v, : *>• 4 . Work to be continued on the Identification of the > ^ sugars combined in glycoalkaloid moieties, . ^ ^ : v- /’ 5» Test animals to be used to determine the presence % _ : - of the active principled s) In various fractions. 6. When the giycoalkalold(s) or/and alkaloid(s) have ' , ;v .been Isolated work will be undertaken to determine their physiological activity on laboratory test ; animals, their physical and chemical properties . including ultraviolet and Infrared spectra. _ 7. If the alkalbid(s) cannot be identified as known alkaloid(s), work will be instituted to elucidate ^ ‘ the structure, ^ - it is estimated that this investigation will require from three to five years to complete. , . WARNING NOTICE SFN*mw mrct 1