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I ' r • o ' : ' rr~'~~~cT / PROPOSED RESEARCH PROJECTS FOR 1957-58 Human volunteers - Atlanta Federal Penitentiary W- 0 ? potentiation of LSD-25 psychosis with cortisone 2. Triais of new hallucinogenic agents ^ iDibenamine and Dibenzyl ine as antagonists to LSO-25 • 4. Search for new antagonists to LSD-25 .... 5. Trials of the so-called inactive isomer i-LSD-25 as a hallucinogen 6. Trials of other CNS active drugs B Ph3 rtnacol og i ca 1 and biochemical studies 2 . 3- 4 . 5. 6. 7. in vitro studies of candidate hal lucinogens on enzyme systems a. Cholinesterases, b. Mono- and diamine oxidases, c. Glucose metabolism of S. cerevisiae, d. d-amino acid oxidase Effect of candidate compounds on rabbit body temperature Effect on activity of mice Gaddum rat uterus - inhibition of J-HTr^ Pharmacodynami c studies in the anesthetized dog , . . Chronic toxicity and safety studies on promising compounds before trial in man Pharmacodynamic studies on optically active esters of choline C. Chemical synthetic program 1. Synthesis of substituted piperidine carboxamides 2. Synthesis of aryl alkyl amine derivatives 3. Synthesis of indolyl alkyl amine 4. Synthesis of optically active esters of choline 5. Synthesis of a few additional salts of 2-dimethylammoethanoI D. Clinical studies in schizophrenia » 1. Continued trials of 2-dimethylaminoethanol in patients .... 2. Trial of naturally occurring sulph hydry l compounds in schizophrenia WARDING NtyUQE SENSITIVE INTEt/lGErKE SOURCES AND METHODS INVOLVED *