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/ The experimental subjects are a group of sixteen volunte-ers, l U. S. Federal Penitentiary at Atlanta, Georgia. HcaUhy .and csnotional ly _ t determined by psychometric tests) individuals are chosen. Their mean JSC £[ esenV if^years, their mean weight is 160 pounds. Their I.Qs. range iron $0 to *23- Th"e~ doses of drugs are administered at random at weekly interva s. J 1 * have exoariencedThe effects of central nervous system stimulants and depressants, ^y ait: to fy and to communicate the subjective responses to these drugs and have proven that their responses are sonewhat reproducible. Tests are carried out «qa hospital room. The subjects are encouraged to stay in hVd durina the trials. Chugs are administered orally, two hours a ^ er 9 * a n na^breakfast jilt ng fa usual iy done single or double blind. The dru9 sare_ S d 9 to eacJ Jbjelt H mall labeled bottlf. The label bears only the name of the subject^ The subjects place the tablets or capsules in their mouth under supervision of the physician and wash them down with a cup of J ,avore W ?he evaluation of the drug effects is based on throe types of responses. A Observations are made by the attending doctor during a three-hour tes t pe^ _ following administration of the drug. These include P sure, pulse rate, body temperature and hand stead, ness at 60 or 90 *tus intervals. It also includes observations on the neurological and mental status _ of the subjects, such as alertness, sleep and arousal from sleep. b A oersonal interview is made at the end of the three-hour period. In this jnter- Clew Se suijecl !! encouraged to tellJiiS feelings under the Influence of the drug and canpares them with similar or dissimilar effects which he may have ex perienced with the other drugs on previous trials. C. Twenty-four hour statement. The subjects prepare a written statement^ the ef- fects^xperienced in the twenty-four hour period after the admini strat ion of t e ! X iuHrli for the effects were .iUbl.lsK.fb, the subjects thrives. Subjects were told either after the Interview orafter they had ' written statement which drug and dose had been administered. This '" cr ®3 * 3 ! their degree of drug sophistication and allots them to evaluate new drug effects.