◆ SpookStack

H* -1,4 COMPOUNDS HAVING A POTENTIAL EPrECT UPON THE CENTRAL lrfiRVOUS SYSTEM WITH SMFHASIS UPON MOIETIES ORIGINATING KALLUCIMTORY REACTS by « d- OUTLINE of Fourth Report (January 1, - Nay JO, 1957) I. 7hs v.'ork was continued in accordance with the outline of the Third Report, submitted in December 19j^« A. Substituted Piperidinecarboxamdes : (1) compounds synthesised and postulated structure confirmed!. a. 1 -raethyl -J-(N-!aethylcerboximido)-l^2,J,6- tetrahydropyridine hydrochloride (C-j6) b. 1-rae Ihy 1 -J- (N- e thyl car boxer,! do ) - 1 , 2,5,6-teirahydropyridine hydrochloride (G-J7) , , . , n c. l,l-bis/J-(N,N-di ethyl carboxeni do Jpiperidino/aethane IG-10T; (2) work in progress: . . a. synthesis of l-raethyl^-phenyl-4-(K,^dieUrylcarbox&mido;?iperi- dine hydrochloride (G~JS) B. Arylalkylaraine Derivatives! (l) compounds synthesized and postulated structure confirmed.! a, N,!;-diethyl-,t”bromopropionamide (GI-10J, X), intermediate . b. N-phene thyl-N-'metJryl-,i-alamne diethylamide hydrochloride (Gl-104, XI J . Indolvlalkylardne Derivatives: (1) cos pounds synthesized and postulated structure confirmed : a. ^-(N,ll“diethylanino)butyl 5,^,5-triijethoxybenzoate (GI*v,OJJ XXIX), ali- phatic analogue of reserpine b. 4-(K, N-dicthyl amino )bulyroruiril e (GI-551, mill), intermediate c. 4-(lI,K-di ethyl emino)butyl amine (GI-JJ2, XXXI V), intermediate (2) work in prdgress! ** , a. synthesis of ll-fh-Oh N-d i ethyl ami r.o) butyl/-}, * , J- tr ime .hoxyber.z- eride (GI-JpJ, XXX), aliohatic analogue of reserpine b. synthesis of l.'-formyl tr ypta.minc (C-I-201, XIV), intermediate n addition to the work already in progress, new projects have been underta- en. A Utilizing the products of the effect of gradual cha: our synthetic program, we are planning to study igcs in molecular crr.stitution upon enzymes as-