◆ SpookStack

f X 3. o integration of four leads, one from each lobe of a hemicranium. Also under construction is a quantitative spectral analyzer for use with the tape recorder in analyzing scalp EEG of humans as well as electrical measurements from implanted electrodes in cortex and deeper structures in brains of animals. Data will be entered on punch cards and processed by a digital computer. Target date for beginning calibration and stan- dardization is June 1, 1962. These new approaches allow determination with great accuracy of effects of various classes of compounds and the interactions of such agents. A Barber Colman gas chromatograph has been installed and a technician is being trained to operate it. This makes possible correlative studies of changes in brain constituents, changes in behavioral state, and electro physiological data. This method is far more sensitive than previous techniques, and allows accurate measurements to be made from much smaller brain fractions. A Beckman pH meter and microburette have also been obtained for study of cholinesterase activity, since it appears that psychotomimetic effects frequently if not always involve atropine-like drug action (Pfeiffer, C.C., et al. Neurology, 9: 249-250, 1959) Recent and current projects : These new techniques, together with the unique availability of human subjects both normal and abnormal, make possible a wide range of investigations on any class of compounds with action on the central nervous system. These can begin at the most basic level and move progressively to a level of sophistication beyond that of almost any other setting. Some idea of the directions currently being taken are indicated in recent and current work. Enclosed are -reprints of publications during the past year. The following are also accepted for pubiication and. will appear in the next few months: d-